Romina (E.) L.
Principal Scientist
Experience
Oct 2023 - Aug 2025
1 year 11 monthsBoston, United States
Principal Scientist
Harbinger Health
- Led strategic initiatives to optimize assay platforms, achieving significant cost efficiencies (~$27 per sample) while maintaining performance for scalable commercial deployment.
- Directed adoption and standardization of innovative cfDNA-like control materials across workflows, reducing development and automation costs by 30%.
- Proactively initiated and managed cross-functional collaborations with biotech companies and academic partners to evaluate emerging pre-commercial technologies, shaping assay strategy and innovation pipelines.
- Guided exploratory mutation and biomarker analyses using multi-omics datasets and public databases (e.g., COSMIC), providing actionable insights for assay design, clinical prioritization, and product differentiation.
- Advised on strategies to expand the clinical utility of hybrid capture panels, supporting ongoing innovation in cfDNA-based diagnostics.
- Partnered with Data Science and Bioinformatics teams to prioritize lung cancer gene targets, integrating clinical evidence, regulatory considerations, and competitive intelligence.
- Conducted competitive landscape assessments and scientific surveillance to inform regulatory strategy, market positioning, and internal R&D priorities.
- Represented Harbinger at the 2025 Festival of Genomics Boston, synthesizing insights on competitor activity, biomarker innovation, and translational opportunities for leadership and stakeholders.
Jul 2022 - Present
3 years 5 monthsIndependent Genomics & Oncology Consultant
Independent Genomics & Oncology Consultant
- Advise consulting firms and biopharma clients on genomics, NGS workflows, and biomarker strategies for R&D, diagnostics, and investment evaluations.
- Provide strategic guidance on early-stage oncology diagnostic platforms, supporting clinical positioning, regulatory planning, and competitive differentiation.
- Translate complex scientific data into actionable insights to support due diligence, value-based recommendations, and strategic planning.
- Identify clinically meaningful endpoints and emerging biomarker trends to inform companion diagnostic development.
Jan 2021 - May 2022
1 year 5 monthsNew York, United States
Associate Director, Next Generation Sequencing
Columbia University
- Directed NGS operations and assay development for clinical and translational research, optimizing workflows to increase throughput and broaden sample eligibility.
- Led cross-functional initiatives to implement sequencing best practices, ensuring data quality, reproducibility, and operational efficiency across projects.
- Managed technical teams and coordinated biobanking and sample management, maintaining compliance with institutional standards while supporting high-impact research programs.
- Provided strategic input on assay optimization and translational genomics studies, bridging scientific innovation with clinical research goals.
Jan 2019 - Dec 2020
2 yearsNew York, United States
Associate Research Scientist
Columbia University
- Guided multi-omics research programs (RNA-seq, scRNA-seq, ChIP-seq) to support biomarker discovery and translational oncology projects.
- Developed scientific strategies linking epigenetic regulators to potential clinical biomarkers, informing project prioritization and translational decision-making.
- Collaborated across departments to integrate genomic insights into research planning, grant proposals, and cross-disciplinary initiatives.
Jan 2017 - Dec 2018
2 yearsBuenos Aires, Argentina
Volunteer
University of Buenos Aires
- Contributed to translational research on telomere length in MODY-type diabetes, integrating molecular insights into clinical research.
Jan 2013 - Dec 2017
5 yearsBoston, United States
Postdoctoral Research Fellow
Dana-Farber Cancer Institute / Harvard Medical School
- Applied high-throughput epigenomic approaches to map cancer risk alleles and regulatory mechanisms.
- Developed allelic imbalance assays and discovered androgen receptor cistrome reprogramming, informing therapeutic strategies.
Summary
Accomplished scientific leader with 15+ years of experience in translational genomics, oncology biomarkers, and precision medicine.
Expert in cfDNA, methylation signatures, NGS workflows, and biomarker-driven diagnostics.
Proven ability to guide cross-functional programs, translate complex genomics into actionable insights, and influence strategic decision-making for biotech, diagnostic, and investment teams.
Experienced in scientific communications, regulatory alignment, and clinical strategy development.
Languages
Spanish
NativeEnglish
AdvancedFrench
AdvancedGerman
IntermediateItalian
IntermediateEducation
University of Buenos Aires
Biochemist · Basic Biochemistry Orientation · Buenos Aires, Argentina
Ruprecht-Karls-Universität Heidelberg
Ph.D. · Molecular Genetic Epidemiology · Heidelberg, Germany
Certifications & licenses
Innovation and Strategy
Harvard Division of Continuing Education
Starting a Business
MOBI, Santa Clara University
Epigenetics in Cancer Progression
Dana-Farber Cancer Institute
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