Mehrdad (Mike) S.
Supervisor of Formulation and Manufacturing
Experience
Sep 2023 - Present
2 years 3 monthsPleasanton, United States
Supervisor of Formulation and Manufacturing
Thermo Fisher Scientific
- Design and synthesis of novel linker for Antibody-Oligo conjugates (AOCs).
- Design and synthesis of small molecule fluorophores and quenchers, linkers (multi-step synthesis).
- Lead and manage a team of fifteen senior and junior chemists in production and process development of small molecules, fluorescent dyes, quenchers, nucleotides, and linkers for multiple projects of the genetic science division and external customers ($4.4 million annual revenue and $0.9 million annual PPI saving).
- Oversee daily manufacturing operations to consistently achieve KPIs: 99% first pass yield, 99.5% on-time delivery, 100% safety score, and 88% headcount utilization.
- Drive continuous improvement through PPI Kaizen initiatives and collaborate cross-functionally with manufacturing sciences, R&D, PPI, planning, and procurement teams to support NPIs and optimize processes.
- Lead problem-solving meetings to resolve production issues and customer complaints efficiently.
- Monitor aging materials and coordinate retesting and requalification with QC and IQC teams to maintain quality standards.
- Facilitate cross-functional meetings involving QA, IQC, and QC for raw material procurement, vendor changes, and approval of new vendor contracts.
Apr 2023 - Sep 2023
6 monthsSan Diego, United States
Research Scientist, Bioconjugation Chemistry
Proteogenomics Research Institute for System Medicine (PRISM)
- Design and synthesis of novel linker for Antibody-drug conjugates (ADCs).
- Synthesis, purification, and characterization of ADCs via dialysis, SEC-UV, and MALDI.
- Develop a strategy to conjugate polymer-drug with receptor-targeted antibody for cancer therapy.
Nov 2021 - Dec 2022
1 year 2 monthsPleasanton, United States
Scientist III
Thermo Fisher Scientific
- Design and synthesis of small molecule fluorophores and quenchers (multi-step synthesis).
- Purification of small molecules using TLC, flash chromatography, Biotage, HPLC, UPLC, and UPLC-MS.
- Characterization of small molecules by NMR, MS, UV-Vis, and fluorometry.
Jan 2018 - Aug 2021
3 years 8 monthsPostdoctoral Research Associate
University of Nebraska–Lincoln; University of Virginia, Cliff Stains Lab
- Design and synthesis of small molecule fluorogenic fluorophores.
- Design and synthesis of second window near-infrared fluorophores.
- Mentoring and training undergraduate researchers and new graduate students.
- Safety officer responsibilities.
- Lab manager responsibilities.
Aug 2011 - Dec 2017
6 years 5 monthsTucson, United States
Research Assistant, Department of Chemistry and Biochemistry
University of Arizona
- Design and synthesis of Triazabutadiene-based coumarins for fluorescent labeling of tyrosine residues in proteins.
- Design and synthesis of a cleavable fluorogenic system including cyclooctyne triazabutadiene and azido coumarin for tyrosine modification of proteins.
- Scale-up synthesis of small molecules and fluorophores to gram scale (up to 100 grams).
- Mentoring and training undergraduate researchers and new graduate students.
Jan 2009 - Aug 2011
2 years 8 monthsEdwardsville, United States
Research Assistant, Department of Chemistry
Southern Illinois University Edwardsville
- Design and synthesis of a library of fluorinated bioactive small heterocyclic molecules.
- Purification of small organic molecules by recrystallization, flash chromatography, prep-TLC, and GC.
- Characterization of organic small molecules by NMR, 2D NMR, IR, GC, MS, and UV-Vis.
Summary
- Organic chemist with 12+ years of experience in chemistry methodology development, analytical characterization, and bioconjugation strategies.
- Advanced academic training and industry experience in synthesis, purification (including different types of chromatography), and characterization (including different types of instrumental analysis) of small molecules and fluorescent probes for chemical biology, drug delivery, and medicinal chemistry purposes.
- Highly proficient skills in technical and non-technical communication, and preparation of reports, SOPs and scientific and non-scientific presentations
Languages
English
NativePersian
IntermediateEducation
Oct 2011 - Jun 2017
University of Arizona
Ph.D. · Organic Chemistry · Tucson, United States
Oct 2009 - Jun 2011
Southern Illinois University Edwardsville
M.S. · Organic Chemistry · Edwardsville, United States
Oct 2003 - Jun 2007
Tehran University
B.S. · Applied Chemistry · Tehran, Iran, Islamic Republic of
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