Mandeep S.
Principal Scientist
Experience
Dec 2023 - Present
2 yearsPrincipal Scientist
NuChem Sciences (now part of Sygnature Discovery)
- Lead multigram-scale synthesis, process development, and optimization of drug discovery molecules within a global CRO platform.
- Manage cross-site projects and client communications, ensuring seamless milestone delivery across Canadian and European teams.
- Mentor and supervise junior scientists, improving efficiency, knowledge transfer, and scientific rigor.
Nov 2020 - Nov 2023
3 years 1 monthSenior Scientist II / Senior Scientist I / Scientist
NuChem Sciences (now part of Sygnature Discovery)
- Designed and executed synthetic routes for 20+ novel molecules, directly supporting biotech and pharma R&D programs.
- Developed and optimized scale-up strategies, addressing diverse synthetic challenges to ensure reproducibility and project continuity from milligram to multigram scale.
- Coordinated weekly project updates with international clients, enhancing transparency and contributing to repeat business.
- Supported multiple successful project completions that contributed to NuChem’s strategic growth and its acquisition by Sygnature Discovery.
Sep 2017 - Aug 2019
2 yearsDr. D.S. Kothari Post-Doctoral Fellow
University of Delhi
- Developed innovative synthetic strategies to overcome challenges in ongoing Ph.D. projects.
- Designed alternative pathways and mentored three graduate students toward successful thesis completions.
Jan 2017 - Aug 2017
8 monthsAssistant Professor (ad-hoc)
University of Delhi
- Delivered Medicinal Chemistry lectures for M.Sc. students and supervised laboratory research projects.
Oct 2015 - Nov 2016
1 year 2 monthsGreater Noida, India
Research Scientist
Teva API India Pvt. Ltd.
- Led a team of 4 chemists in developing non-infringing synthetic routes for APIs.
- Identified and scaled new polymorphs through crystallization studies, securing intellectual property opportunities.
- Implemented GMP-compliant impurity profiling, improving readiness for regulatory submissions.
Nov 2012 - Aug 2015
2 years 10 monthsHaifa, Israel
Post-Doctoral Fellow
Technion – Israel Institute of Technology & Open University of Israel
- Synthesized and characterized hetero-bambusurils, a novel family of macrocyclic host molecules.
- Applied crystallization and host-guest binding studies (NMR, UV-Vis) to evaluate molecular interactions.
Summary
Principal Scientist with 12+ years of academic and industrial experience in organic synthesis, drug development, and process optimization. Skilled in designing and scaling up synthetic routes from milligram to multigram scale, impurity profiling, and API development. PMP® certified, with proven expertise in project management, client communication, and team leadership. Recognized for delivering high-impact results in pharmaceutical R&D, mentoring researchers, and driving innovation across diverse chemical projects
Languages
Punjabi
NativeEnglish
AdvancedHindi
AdvancedEducation
Apr 2007 - Apr 2013
University of Pune
Ph.D. · Chemistry · India
Oct 2005 - Jun 2007
University of Delhi
M.Sc. · Organic Chemistry · India · Gold Medalist
Oct 2001 - Jun 2004
University of Delhi
B.Sc. · Chemistry · India
Certifications & licenses
Project Management Professional (PMP)®
PMI
Essential Management Skills Program
McGill Executive Institute
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