Jigyasa S.
TCGA-BRCA Transcriptomics Expression Analysis
Experience
Mar 2025 - Apr 2025
2 monthsTCGA-BRCA Transcriptomics Expression Analysis
GitHub Project
- Identified 500+ DEGs across breast cancer subtypes using PCA, volcano plots, and FDR-corrected Wilcoxon tests.
- Conducted GO/KEGG enrichment to reveal subtype pathways (e.g., p53) using Python pipeline and visual outputs.
Jan 2025 - Apr 2025
4 monthsBoston, United States
Protein Analysis Using LC-MS and AlphaFold
Northeastern University
- Analyzed 1,154-residue JAK1 using LC-MS, BLAST, and AlphaFold to assess peptide uniqueness and structural confidence.
- Computed 183.9 Å Cα-Cα distance from PDB and evaluated top-down proteomics feasibility based on structure and PTMs.
Jul 2024 - Dec 2024
6 monthsNatick, United States
Data Science Intern
ActivSignal
- Automated NGS & qPCR data processing for 10M+ data points, with statistical evaluation, outlier detection, and CV analysis.
- Refined data integration & visualization (volcano plot, heatmap, PCA/t-SNE) for 100+ samples, cutting analysis time by 50%.
- Parallelized job execution in Galaxy, optimizing resource use across 16-96 vCPUs for NGS processing.
- Optimized Galaxy workflows on AWS (LightSail, EC2), cutting 1B-read processing time by 76% via 48 vCPU runs.
- Designed a real-time analytical dashboard for a 245-sample Proteogenix Plasma study, accelerating reporting time by 60%.
- Implemented molecular docking in AutoDock Vina to optimize ligand-receptor interactions and assess binding affinities.
Jul 2024 - Aug 2024
2 monthsBreast Cancer Classification Using ML Models
GitHub Project
- Classified Breast Cancer Coimbra data using Logistic Regression, Random Forest, and SVM, achieving 81.7% balanced accuracy.
- Enhanced model performance through feature engineering, PCA, and ensemble methods for improved predictions.
Feb 2024 - Mar 2024
2 monthsBoston, United States
Rats and MultiQC
Northeastern University
- Executed quality control on rat sequencing data (SRR10901552) and generated MultiQC reports.
- Identified the impact of deduplication, trimming, and contaminant removal on read quality.
Aug 2023 - Dec 2023
5 monthsBoston, United States
RNA-Seq Analysis of Mus musculus Transcriptome
Northeastern University
- Performed RNA-seq data analysis using Kallisto for gene expression quantification and transcript annotation.
Jan 2023 - Apr 2023
4 monthsNew Delhi, India
Research Intern
CSIR- Institute of Genomics and Integrative Biology
- Assessed 10+ somatic mutation calling tools via literature review and computational assessment.
- Applied statistical methods to evaluate tool accuracy, sensitivity, and specificity across 1,000+ variants.
Jun 2022 - Jul 2022
2 monthsNew Delhi, India
Research Intern
CSIR-Innovation Protection Unit
- Mapped RT-PCR-based COVID-19 diagnostic tools and conducted docking studies on viral proteins.
- Used AutoDock & PyMol to model viral proteins and simulate ligand interactions, identifying 4 novel therapeutic targets.
Jun 2021 - Jul 2021
2 monthsNoida, India
Student Researcher
Amity University
- Conducted a research study on the role of hormones like Estrogen and Gonadotropins in Alzheimer's Disease.
- Studied hormone interactions using KEGG pathway analysis, collaborating with faculty to refine methods.
Summary
Bioinformatics Master's student with hands-on experience in protein bioinformatics, transcriptomics, and machine learning pipelines for biological classification and enrichment. Seeking research roles to apply expertise in coding, computational biology, genomics, and data analysis.
Languages
English
NativeEducation
Sep 2023 - Dec 2025
Northeastern University
Master of Science, Bioinformatics · Boston, United States
Aug 2019 - Jul 2023
Amity University
Bachelor of Technology, Biotechnology · India
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