Don Clarke

Medical Research Scientist

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Carlsbad, United States

Experience

Jan 2023 - Present
3 years
San Diego, United States

Medical Research Scientist

Sanford Burnham Prebys – Marth Lab

  • Constructed a comprehensive single-cell B-cell pipeline from probe production to antibody characterization.
  • Developed a glyco-engineered cell-surface expression system to identify glyco-protein specific antibody targets from polyclonal plasma.
  • Isolated and characterized tumor-associated glycan-specific antibodies.
Jan 2017 - Dec 2023
7 years
San Diego, United States

PhD & Postdoctoral Researcher

Scripps Research – Teyton Lab

  • Developed microfluidic RT-PCR tools for high-precision primary T-cell analysis.
  • Used single-cell RNA-seq to isolate and characterize rare antigen-presenting cells.
  • Generated NFAT responsive tools for studying T-cell activation.
Jan 2015 - Dec 2017
3 years
Torrance, United States

Research Scientist

Phoenix Nest Inc.

  • Designed a preclinical proof-of-concept autologous stem-cell gene therapy targeting MPS IIIB.
  • Leveraged iPSC-derived neural stem cells for innovative CNS enzyme-replacement strategies.
  • Produced in vivo and iPSC-NSC data that enabled Cure Sanfilippo Foundation funding (2018) and subsequent MPS IIIB publications (2018, 2022).

Summary

Innovative molecular biologist with advanced expertise in stem cell biology, immunology, and glycobiology. Proven track record of developing cutting-edge research tools, characterizing rare cell populations, and translating scientific discoveries into potential therapeutic applications. Catalyzed more than $3.2M in external funding to date through data I generated and led into funded applications.

Skills

  • Single-cell Analysis
  • Immunological Research
  • Stem-cell Engineering
  • Advanced Molecular Techniques
  • Antibody Characterization
  • Precision Cell Sorting
  • Cellular Technologies: Single-cell Facs, Spectral Flow, Plate-seq; Ipsc Generation & Differentiation, Primary-cell Isolation, And Advanced Microscopy
  • Molecular Biology: Restriction Cloning, Gibson, Gateway; Pseudo-virus & Biosensor Line Engineering; Mammalian & Drosophila Expression Systems
  • Computational Analysis: Data Processing And Visualization In Python (Pandas, Scikit-learn, Matplotlib) And R (Tidyverse, Bioconductor, Seurat)

Languages

English
Native

Education

Oct 2017 - Jun 2023

Scripps Research Institute

Ph.D., Chemical & Biological Sciences · Chemical & Biological Sciences · San Diego, United States

Oct 2011 - Jun 2015

California State University, Los Angeles

M.S., Biology · Biology · Los Angeles, United States

Oct 2007 - Jun 2011

University of California, Los Angeles

B.A., Geography · Geography · Los Angeles, United States

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