Ziming Huang
Research Scientist
Experience
Research Scientist
LMU Klinikum and Helmholtz München
- Spearheaded collaborative research projects in cardiovascular immunology, utilizing scRNA-seq analysis to elucidate the molecular mechanisms of complement component 5a signaling in innate immune macrophages
- Drove the discovery and validation of novel genes and pathways in cardiomyopathies by integrating complex clinical and real-world datasets (e.g., SNP genotyping, electronic medical records)
- Engineered a novel 1DCNN-Transformer hybrid architecture for miRNA-mRNA binding prediction directly from DNA sequences achieving SOTA performance with a superior AUC of 0.903 that significantly reduced false-positive rates compared to benchmark models, released on [link]
AI Scientist
Kaggle Competition – Molecular Translation
- Led a 4-person team to achieve 2nd place among 874 competitors (Kaggle Grandmaster Top 0.1%) in the Molecular Translation Challenge, successfully solving the critical data transformation challenge of low OCR accuracy on a large, corrupted FDA-sourced chemical molecular scanned image dataset
- Engineered a 3-phase model featuring ResNet-Transformer image captioning, candidate generation, and multi-model re-ranking
- Boosted model robustness by 40% through molecular-specific data augmentation, achieving an Edit Distance of 0.54 (vs. baseline 0.9+), and enabling accurate conversion of 1.6 million legacy chemical scanned images into machine-readable InChI format
Research Scientist
Shanghai Institute of Materia Medica
- Resolved API integration codes for models like GPT-3.5-turbo in chemical text-mining tasks, and designed batch data transfer strategies to support large-scale chemical literature processing
- Conducted structure-based virtual screening to identify potential inhibitors targeting the interaction between SARS-CoV-2 spike protein receptor-binding domain and host cell angiotensin-converting enzyme 2, which is a key step in viral entry into host cells
- Engineered and validated a Random Forest model for Immune Checkpoint Inhibitor (ICI) response prediction using multi-omics data from 281 cancer patients, achieving a state-of-the-art AUC of 0.85 on external validation, significantly surpassing the baseline model (AUC, 0.763), and identifying novel biomarkers enriched in crucial immune pathways
Intern
BGI Genomics
- Engineered a bit-parallel fuzzy regex pipeline to perform SNP-tolerant cross-species comparative genomics on five Takifugu species, enabling automated annotation of conserved genomic sites
- Achieved a 10-time speedup in querying and accessing 30 GB of genome annotation data using a MySQL database (python library), significantly improving the efficiency of comparative analysis
- Based on above results, automated the entire RNA-Seq analysis pipeline in Linux, from read mapping and data cleaning to gene annotation, standardizing the workflow for high-throughput data processing
Data Scientist
National Mathematical Modeling Competition
- Achieved the National second Prize (among Graduates) in the competition, served as lead model developer and scientific writer
- Developed and applied a Logistic Regression model combined with GWAS statistical testing on 9445 SNPs to accurately identify the three most likely disease-associated loci for the target-inherited disease within 300 provided genes
Industries Experience
See where this freelancer has spent most of their professional time. Longer bars indicate deeper hands-on experience, while shorter ones reflect targeted or project-based work.
Experienced in Biotechnology (7.5 years), Healthcare (3.5 years), Pharmaceutical (3.5 years), and Chemical (0.5 years).
Business Areas Experience
The graph below provides a cumulative view of the freelancer's experience across multiple business areas, calculated from completed and active engagements. It highlights the areas where the freelancer has most frequently contributed to planning, execution, and delivery of business outcomes.
Experienced in Research and Development (7.5 years) and Information Technology (0.5 years).
Skills
- Programming: Python, Pandas, Scikit-learn, Pytorch, Pysql, R, Sas, Git, Jupyter, Vscode, Google Colab
- Life Science: Oncology Research, Cardiology Clinical Research, Immunology, Genetics, Molecular Biology, Cell Biology
- Informatics: Statistics, Mathematical Modeling, Ml&dl, Bayesian Network, Transformer, High Performance Computing (Hpc)
- Bioinformatics/cheminformatics: Scrna-seq Analysis, Rna-seq Analysis, Gwas, Quantitative Structure-activity Relationship (Qsar)
- Scientific: Research Project Management, Academic Writing, Teamwork
Languages
Education
Ludwig-Maximilians-Universität München
PhD candidate in Medical Research · Medical Research · Munich, Germany
University of Chinese Academy of Sciences
Master of Science in AI-assisted Drug Design · AI-assisted Drug Design · China
Huazhong Agricultural University
Bachelor of Science in Bioinformatics · Bioinformatics · Wuhan, China
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