Ziming H.
Research Scientist
Experience
Sep 2022 - Present
3 years 3 monthsMunich, Germany
Research Scientist
LMU University Hospital and Helmholtz Munich
- Spearheaded collaborative research projects in cardiovascular immunology, utilizing scRNA-seq analysis to elucidate the molecular mechanisms of complement component 5a signaling in innate immune macrophages
- Drove the discovery and validation of novel genes and pathways in cardiomyopathies by integrating complex clinical and real-world datasets (e.g., SNP genotyping, electronic medical records)
- Engineered a novel 1DCNN-Transformer hybrid architecture for miRNA-mRNA binding prediction directly from DNA sequences achieving SOTA performance with a superior AUC of 0.903 that significantly reduced false-positive rates compared to benchmark models, released on [link]
Mar 2021 - Jun 2021
4 monthsAI Scientist
Kaggle Competition – Molecular Translation
- Led a 4-person team to achieve 2nd place among 874 competitors (Kaggle Grandmaster Top 0.1%) in the Molecular Translation Challenge, successfully solving the critical data transformation challenge of low OCR accuracy on a large, corrupted FDA-sourced chemical molecular scanned image dataset
- Engineered a 3-phase model featuring ResNet-Transformer image captioning, candidate generation, and multi-model re-ranking
- Boosted model robustness by 40% through molecular-specific data augmentation, achieving an Edit Distance of 0.54 (vs. baseline 0.9+), and enabling accurate conversion of 1.6 million legacy chemical scanned images into machine-readable InChI format
Mar 2019 - Jun 2022
3 years 4 monthsShanghai, China
Research Scientist
Shanghai Institute of Materia Medica
- Resolved API integration codes for models like GPT-3.5-turbo in chemical text-mining tasks, and designed batch data transfer strategies to support large-scale chemical literature processing
- Conducted structure-based virtual screening to identify potential inhibitors targeting the interaction between SARS-CoV-2 spike protein receptor-binding domain and host cell angiotensin-converting enzyme 2, which is a key step in viral entry into host cells
- Engineered and validated a Random Forest model for Immune Checkpoint Inhibitor (ICI) response prediction using multi-omics data from 281 cancer patients, achieving a state-of-the-art AUC of 0.85 on external validation, significantly surpassing the baseline model (AUC, 0.763), and identifying novel biomarkers enriched in crucial immune pathways
Nov 2017 - Jun 2018
8 monthsQingdao, China
Intern
BGI Genomics
- Engineered a bit-parallel fuzzy regex pipeline to perform SNP-tolerant cross-species comparative genomics on five Takifugu species, enabling automated annotation of conserved genomic sites
- Achieved a 10-time speedup in querying and accessing 30 GB of genome annotation data using a MySQL database (python library), significantly improving the efficiency of comparative analysis
- Based on above results, automated the entire RNA-Seq analysis pipeline in Linux, from read mapping and data cleaning to gene annotation, standardizing the workflow for high-throughput data processing
Jun 2016 - Sep 2016
4 monthsWuhan, China
Data Scientist
National Mathematical Modeling Competition
- Achieved the National second Prize (among Graduates) in the competition, served as lead model developer and scientific writer
- Developed and applied a Logistic Regression model combined with GWAS statistical testing on 9445 SNPs to accurately identify the three most likely disease-associated loci for the target-inherited disease within 300 provided genes
Languages
Chinese
NativeEnglish
AdvancedGerman
ElementaryEducation
Sep 2022 - Present
Ludwig Maximilian University of Munich
PhD in Medical Research · Medical Research · Munich, Germany
Sep 2019 - Jun 2022
University of Chinese Academy of Sciences
Master of Science in AI-assisted Drug Design · AI-assisted Drug Design · China
Sep 2014 - Jun 2018
Huazhong Agricultural University
Bachelor of Science in Bioinformatics · Bioinformatics · China
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