Cheng X. - Model Validation 2 - Expert

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Katy, United States

Experience

Sep 2025 - Present

4 months

Model Validation 2 - Expert

Handshake AI

Train and validate AI models - Biology.

Apr 2019 - May 2025

6 years 2 months

Bioinformatics Scientist II

GENOVO Inc

Develop web application of multi-panels bioinformatics analysis system using J2EE platform
Develop and deploy tumor tissues’ somatic mutation detection software for a panel (557 genes) from sequencing data (BCL or Fastq) to somatic mutation detection report in clinical settings
Develop and deploy ctDNA detection software (557 genes in a panel) with a newly developed algorithm for large sequencing data from sequencing data (BCL or Fastq) to somatic mutation report in clinical settings
Develop Automatic Reviewing System to replace manual review process
Design and develop clinical variants interpretation database for internal use and integrate this database into clinical report
Develop and deploy WGS detection software with a newly developed algorithm for huge sequencing data (~600 GB)
Use tumor tissues’ somatic mutation detection software to analyze CAP PT test samples and pass CAP PT test for three consecutive years
Use ctDNA detection software to analyze CAP PT test samples and pass CAP PT test
Develop and deploy TCR/BCR CDR3 clonetyping detection software
Design and perform various analytical performance analyses of tissue and ctDNA somatic mutation detection, including precision studies, analytical sensitivity – limit of detection (LoD), traceability, analytical specificity, and assay cut-off
Create QA plan and test for custom designed bioinformatics pipelines
Obtain two China patents of biomarkers: “A Biomarker for Cholangiocarcinoma Detection and Its Applications” (ID: CN117512116A) and “A Probe, Kit, and Applications for Detecting Microsatellite Instability (MSI)” (ID: CN117660655A)

Jul 2017 - Mar 2019

1 year 9 months

United States

Scientist – Department of Epigenetics and Molecular Carcinogenesis

MD Anderson Cancer Center

Explore the role of deletion of AT-hook domain at BRG1 in chromatin remodeling and transcription regulation
Analyze various RNA-seq and related datasets (including PRO-seq, ATAC-seq, RNA-seq, ChIP-seq) to explore the regulatory molecular mechanism underlying the cell developmental change from ground to primed state

Sep 2013 - Jun 2017

3 years 10 months

United States

Postdoctoral Associate – Human Genome Sequencing Center

Baylor College of Medicine

Conduct genomic data analyses on population genomic study of rhesus whole genome sequencing, from variant calling and imputation to downstream analysis of population genomics
Publish “The population genomics of rhesus macaques (Macaca mulatta) based on whole genome sequences” (Genome Research, 2016) and another paper under review
Study base-biased evolution of disease-associated mutations in human genome and publish “The base-biased evolution of disease-associated mutations” (Human Mutation, 2016)

Sep 2010 - Aug 2013

3 years

United States

Scientific Programmer – School of Public Health

University of Texas Science Health Center at Houston

Conduct research in epidemiological genetics and discover genetic mechanisms for racial differences in energy expenditure, athletic capability, and obesity
Participate in NIH-funded project to explore genetic background underlying heart diseases
Perform data analysis and statistical research

Sep 2008 - Aug 2010

2 years

China

Associate Professor

Guangdong Institute for Monitoring Laboratory Animals

Conduct research in the evolution of duplicate genes and propose a new model to explain the preservation of duplicate genes in genomes

Sep 1995 - Jul 2003

7 years 11 months

China

System Administrator

Guangdong Institute for Monitoring Laboratory Animals

Construct the Laboratory Animal Information Network of China as principal investigator
Participate in the selection of laboratory animals for toxicity monitoring of oil exploration contaminants and draft national standards “Biological toxicity grading for pollutant from marine petroleum exploration and exploitation” (GB 18420.1-2001) and “Biological toxicity inspecting method for pollutant from marine petroleum exploration and exploitation” (GB 18420.2-2001)
Participate in the national project “Histological Atlas of Rhesus (Macaca mulatta) and Beagle and Construction of Databases” and independently perform database and software construction