Xiang M.
Scientist III, Chemistry
Experience
Dec 2023 - Present
2 yearsSan Diego, United States
Scientist III, Chemistry
Arrowhead Pharmaceuticals
- Leading chemistry efforts on siRNA therapeutics with a focus on kidney/muscle-targeted delivery and ligand design.
- Optimized oligonucleotide stability and delivery using novel backbone modifications.
- Supporting preclinical pipeline advancement with conjugation chemistry and formulation input.
Sep 2022 - Dec 2023
1 year 4 monthsSan Diego, United States
Scientist I, Chemistry
Ambrx Inc.
- Designed and screened novel cleavable/non-cleavable ADC linkers to enhance tumor selectivity.
- Contributed to antibody functionalization strategies enabling high-DAR ADCs.
- Partnered with biology teams to deliver ADC candidates for in vivo evaluation.
Jan 2019 - Dec 2022
4 yearsSan Diego, United States
Postdoctoral Research Associate
UC San Diego
- Developed photocaged peptides and small molecules for in vivo neuroscience applications.
- Collaborated with pharmacology and imaging teams to evaluate compounds in mouse models.
Jan 2018 - Dec 2019
2 yearsDallas, United States
Postdoctoral Research Associate
UT Southwestern Medical Center
- Applied synthetic and chemical biology approaches to study protein–ligand interactions.
Jan 2018 - Dec 2018
1 yearPasadena, United States
Postdoctoral Research Associate
California Institute of Technology
- Investigated total synthesis and photoactive probe development.
Summary
Ph.D. chemist with 7+ years of biotech and postdoctoral experience in siRNA therapeutics, antibody–drug conjugates (ADCs), and organic synthesis of complex small molecules and peptides. Proven ability to translate cutting-edge chemical biology into therapeutic platforms, including kidney-targeted oligonucleotides, high-DAR ADCs, and photoresponsive drug modalities. Strong record of cross-functional collaboration, process optimization, and mentorship.
Languages
Chinese
NativeEnglish
AdvancedEducation
Oct 2013 - Jun 2017
The Australian National University
Ph.D. · Chemistry · Canberra, Australia
Oct 2010 - Jun 2013
Jinan University
Master · Engineering · Guangzhou, China
Oct 2006 - Jun 2010
Shandong Agriculture University
Bachelor · Engineering · China
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