Xiang M.

Scientist III, Chemistry

San Diego, United States

Experience

Aug 2025 - Present
5 months
Remote

Chemistry AI Trainer & Prompt Engineer

Mercor

Designed and authored domain-specific chemistry prompts and golden responses for supervised fine-tuning and QA evaluation of large language models.

  • Developed structured rubrics to assess instruction-following, reasoning depth, and accuracy in organic and medicinal chemistry tasks.
  • Collaborated with AI evaluation teams to identify model failure modes and improve data quality for scientific reasoning.
  • Contributed to large-scale datasets supporting LLM training in chemical synthesis, reaction mechanisms, and structure–property relationships
Dec 2023 - Present
2 years 1 month
San Diego, United States

Scientist III, Chemistry

Arrowhead Pharmaceuticals

  • Leading chemistry efforts on siRNA therapeutics with a focus on kidney/muscle-targeted delivery and ligand design.
  • Optimized oligonucleotide stability and delivery using novel backbone modifications.
  • Supporting preclinical pipeline advancement with conjugation chemistry and formulation input.
Sep 2022 - Dec 2023
1 year 4 months
San Diego, United States

Scientist I, Chemistry

Ambrx Inc.

  • Designed and screened novel cleavable/non-cleavable ADC linkers to enhance tumor selectivity.
  • Contributed to antibody functionalization strategies enabling high-DAR ADCs.
  • Partnered with biology teams to deliver ADC candidates for in vivo evaluation.
Jan 2019 - Dec 2022
4 years
San Diego, United States

Postdoctoral Research Associate

UC San Diego

  • Developed photocaged peptides and small molecules for in vivo neuroscience applications.
  • Collaborated with pharmacology and imaging teams to evaluate compounds in mouse models.
Jan 2018 - Dec 2019
2 years
Dallas, United States

Postdoctoral Research Associate

UT Southwestern Medical Center

  • Applied synthetic and chemical biology approaches to study protein–ligand interactions.
Jan 2018 - Dec 2018
1 year
Pasadena, United States

Postdoctoral Research Associate

California Institute of Technology

  • Investigated total synthesis and photoactive probe development.

Summary

Ph.D. chemist with 7+ years of biotech and postdoctoral experience in siRNA therapeutics, antibody–drug conjugates (ADCs), and organic synthesis of complex small molecules and peptides. Proven ability to translate cutting-edge chemical biology into therapeutic platforms, including kidney-targeted oligonucleotides, high-DAR ADCs, and photoresponsive drug modalities. Strong record of cross-functional collaboration, process optimization, and mentorship.

Languages

Chinese
Native
English
Advanced

Education

Oct 2013 - Jun 2017

The Australian National University

Ph.D. · Chemistry · Canberra, Australia

Oct 2010 - Jun 2013

Jinan University

Master · Engineering · Guangzhou, China

Oct 2006 - Jun 2010

Shandong Agriculture University

Bachelor · Engineering · China

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