Shengyu Z.
Reviewer
Experience
Jul 2025 - Present
5 monthsReviewer
Handshake AI
- Review tasks submitted by fellows in the Chemistry and Biology Domains for quality control
- Provide professional feedback to guide fellows in production to produce tasks that meet project requirements
- Communicate with domain leaders to stay aligned with the most up-to-date requirements for reviewers
Jun 2025 - Present
6 monthsProduction Fellow in Chemistry and Biology
Handshake AI
- Develop PhD level text- and image-based research questions that cause leading AI model failure in reasoning
- Evaluate AI model failure and provide justifications which identifies key nodes which cause the failure
- Write step-by-step solution in a way that could be followed by people without much experience in the field
Oct 2024 - Present
1 year 2 monthsPostdoctoral Associate
Yale University
- Establish live cell platforms for TRIO activity monitoring and medium/high throughput TRIO modulator screening
- Explore whole-brain imaging approaches for identifying brain regions involved in TRIO-dependent activities
Aug 2019 - May 2020
10 monthsCharlottesville, United States
Teaching Assistant of Introductory College Chemistry II Laboratory
Department of Chemistry, University of Virginia
- Supervised and instructed a total of 96 undergraduate students in two semesters
- Facilitated students' study of chemistry concepts and experimental procedures through a guided inquiry approach in workshops
- Provided feedback on lab technique, ensured proper operation of equipment, and encouraged student-student interaction in laboratory
- Organized students’ presentations and facilitated questions and discussion following presentation
- Graded students’ homework, presentations and discussions, and returned graded materials to students in a timely manner
- Held office hours to address concerns and questions from all students attending this course
- Attended weekly TA meetings
- Maintained a safe working environment in the laboratory
Jul 2019 - Aug 2024
5 years 2 monthsCharlottesville, United States
Ph.D. Student
University of Virginia
- Established a novel design for bioluminescent biosensors by strategically positioning the sensing domain on the luciferin
- Engineered the first genetically encoded bioluminescent potassium indicator combining synthetic chemistry and protein engineering
- Demonstrated applicability of this novel sensor in imaging potassium dynamics in versatile biological systems, including living cells, primary neurons and in vivo
- Paved the way for the development of a series of novel bioluminescent biosensors
- Identified two orthogonal luciferase-luciferin pairs with distinct emission spectra and substrate specificity
- Engineered and optimized the membrane localization of multiple luciferase-channelrhodopsin fusion proteins (luminopsins) based on these orthogonal luciferase-luciferin pairs
- Demonstrated orthogonal membrane potential control in living cells expressing these luminopsins upon luciferin administration
- Achieved orthogonal animal behavior control through the administration of luciferins to mice expressing the different luminopsins, showcasing the potential for neural activity control and brain circuits study
Sep 2017 - Jun 2019
1 year 10 monthsNanjing, China
B.S. Student
Nanjing University
- Innovated in the design of an integrative patch clamp platform equipped with an extra micro-manipulator to accommodate an additional patch pipette for cell substance extraction and subsequent ESI-MS profiling
- Identified a variety of cellular metabolites by precisely extracting cellular contents for ESI-MS profiling after cellular activity was detected during patch clamp recordings
Languages
Chinese
NativeEnglish
AdvancedEducation
Jul 2019 - Aug 2024
University of Virginia
Ph.D. · Chemistry · Charlottesville, United States
Sep 2015 - Jun 2019
Nanjing University
B.S. · Chemistry · Nanjing, China
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