Brandon (Md, phd) C.
Principal Investigator & Associate Professor of Medicine; Assistant Professor of Bioinformatics
Experience
Jan 2020 - Present
5 years 11 monthsPrincipal Investigator & Associate Professor of Medicine; Assistant Professor of Bioinformatics
UT Southwestern Medical Center
- Lead a multidisciplinary laboratory focusing on AI-guided CAR-T cell design and tumor microenvironment engineering
- Pioneer novel CAR-T constructs with logic-gated activation systems, reducing on-target/off-tumor toxicity by 73% in preclinical models
- Created machine learning platform analyzing multi-omic data from 12,000+ cancer patients, identifying 47 predictive immunotherapy biomarkers
- Developed spatial transcriptomics pipeline integrating AI image analysis to map immune-tumor interactions in solid cancers
- Led computational modeling for precision combination therapies, resulting in three ongoing clinical trials
- Principal Investigator for Phase I trials testing novel CAR-T constructs in pancreatic cancer and glioblastoma
- Co-developed FDA breakthrough-designated diagnostic assay predicting checkpoint inhibitor response (89% sensitivity, 84% specificity)
- Secured $8.7M in competitive grants from NIH, DOD, and CPRIT
- Associate Professor of Medicine in Hematology-Oncology Division, providing advanced clinical care and early-phase trial leadership for cellular immunotherapies
- Established first Computational Oncology Clinic integrating AI decision support and institutional CAR-T program growth to 140+ patients annually
- Director of the Computational Oncology Fellowship Program and Course Director for "AI & Machine Learning in Clinical Oncology"
- Mentor to clinical fellows, PhD students, and postdoctoral researchers; recipient of Excellence in Graduate Medical Education Teaching Awards (2022, 2024)
Jan 2019 - Dec 2020
2 yearsPost-Doctoral Research Fellow
Dana-Farber Cancer Institute, Harvard Medical School
- Advanced training in computational oncology and systems biology
- Developed bioinformatics pipelines for multi-omic data integration and tumor microenvironment modeling
- Collaborated on translational research bridging laboratory findings to clinical applications
Jan 2016 - Dec 2019
4 yearsFellow in Hematology-Oncology
Memorial Sloan Kettering Cancer Center
- Specialized in cellular immunotherapy and CAR-T engineering
- Received Outstanding Fellow Award in 2019
- Designed and conducted clinical and translational research studies in hematologic malignancies
Jan 2013 - Dec 2016
4 yearsResident in Internal Medicine
Massachusetts General Hospital, Harvard Medical School
- Completed residency in internal medicine, including comprehensive training in adult inpatient and outpatient care
- Served as Chief Resident from 2015 to 2016, receiving Excellence in Clinical Practice Award
Summary
Board-certified Medical Oncologist and Hematology-Oncology specialist with 9+ years of specialized clinical experience at premier academic medical centers, combining advanced medical expertise with pioneering research in cancer immunotherapy and computational oncology. Recognized leader in translating cutting-edge biomedical discoveries into clinical applications, with particular emphasis on CAR-T cell engineering, tumor microenvironment modeling, and AI-driven predictive oncology. Published researcher with demonstrated success in developing novel immunotherapeutic frameworks, advancing precision treatment protocols, and bridging the gap between laboratory innovation and patient care.
- Cancer Immunotherapy Innovation
- Clinical Trial Design
- Machine Learning in Oncology
- Genomic Medicine
- Translational Research
- Cross-Disciplinary Collaboration
- Medical Education
- Biomarker Discovery
Languages
English
NativeEducation
Oct 2009 - Jun 2013
Johns Hopkins University School of Medicine
Doctor of Medicine · United States
Oct 2008 - Jun 2013
Johns Hopkins University
Doctor of Philosophy · Immunology · United States
Certifications & licenses
American Board Of Internal Medicine, Hematology
American Board Of Internal Medicine, Medical Oncology
American Board Of Internal Medicine
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